Heavy-Ion Microbeam System at JAEA-Takasaki for Microbeam Biology

Use of Microbeam at Jaea Takasaki

The TIARA facilities of JAEA in Takasaki is equipped with a several-MeV light-ion and a several-dozen-MeV heavy-ion microbeam formation systems of focusing type, and a several-hundred-MeV heavy-ion microbeam formation system of collimating type. The microbeams with a spot size of 1 μm or less in diameter are extensively utilized for the research in materials science and biotechnology. An in-air...

A Laser Microbeam Implemented at the Heavy-Ion Microbeam Facility

The heavy-ion microbeam is used for targeted irradiation of living cells (in culture) with ions from the UNILAC linear accelerator of GSI [1]. A custom-made epifluorescence microscope is available for beam targeting as well as for observation of proteins (tagged by fluorescent dyes) in sub-compartments of interest. In order to gain better insight into DNA damage repair processes, we intend to e...

The GSI heavy ion microbeam

Region-specific irradiation system with heavy-ion microbeam for active individuals of Caenorhabditis elegans

Radiation may affect essential functions and behaviors such as locomotion, feeding, learning and memory. Although whole-body irradiation has been shown to reduce motility in the nematode Caenorhabditis elegans, the detailed mechanism responsible for this effect remains unknown. Targeted irradiation of the nerve ring responsible for sensory integration and information processing would allow us t...

Microbeam-integrated multiphoton imaging system.

Multiphoton microscopy has been added to the array of imaging techniques at the endstation for the Microbeam II cell irradiator at Columbia University's Radiological Research Accelerator Facility (RARAF). This three-dimensional (3D), laser-scanning microscope functions through multiphoton excitation, providing an enhanced imaging routine during radiation experiments with tissuelike samples, suc...